The lymph node microenvironment and its role in the progression of metastatic cancer
Identifieur interne : 001709 ( Main/Exploration ); précédent : 001708; suivant : 001710The lymph node microenvironment and its role in the progression of metastatic cancer
Auteurs : Ethel R. Pereira ; Dennis Jones ; Keehoon Jung ; Timothy P. PaderaSource :
- Seminars in cell & developmental biology [ 1084-9521 ] ; 2015.
Abstract
Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.
Url:
DOI: 10.1016/j.semcdb.2015.01.008
PubMed: 25620792
PubMed Central: 4397158
Affiliations:
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